Kaftrio* (Elexacaftor/Tezacaftor/Ivacaftor)

$14,950.00 – $17,057.00

Kaftrio (elexacaftor/tezacaftor/ivacaftor)* is a medication used in combination with ivacaftor 150 mg tablets for the treatment of cystic fibrosis (CF), indicated for CF patients aged 12 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

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What is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for?

Kaftrio (elexacaftor/tezacaftor/ivacaftor)* is a medication used in combination with ivacaftor 150 mg tablets for people with cystic fibrosis (CF) aged 12 years and older with at least one copy of the F508del mutation.

How effective is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for cystic fibrosis?

The approval of Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for CF was based on two clinical studies.

Study 1

Included 403 people with CF, 12 years and older, with one copy of the F508del mutation and a mutation defined in the study. Kaftrio was compared with placebo (a dummy treatment).

According to the study results published:

After 24 weeks, lung function (FEV1) improved significantly.

Study 2

Included 107 people with CF, 12 years and older, with two copies of the F508del mutation. Kaftrio and ivacaftor was compared with ivacaftor and tezacaftor (Symdeko).

According to the study results published:

There was significant improvement in lung function (FEV1).

For more details refer to the prescribing information at the bottom of the page.

Which side effects can I expect with Kaftrio (elexacaftor/tezacaftor/ivacaftor)*?

According to the studies published ,the main common side effects of Kaftrio (which may affect more than 1 in 10 people) in people with CF aged 12 years and older include headaches, upper respiratory tract infections, abdominal pains, diarrhea and rashes.

Please note this is not intended to be a comprehensive guide. Consult your treating doctor and the prescribing information at the bottom of the page for full details of side effects.

How is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* taken?

Administration: in the morning take two Kaftrio tablets. In the evening, take one ivacaftor tablet. Take these tablets approximately 12 hours apart.

Dosage: 150 mg ivacaftor, 100 mg tezacaftor and 200 mg elexacaftor in the morning and 150 mg ivacaftor in the evening.

Tablets

56 tablets – 75 mg of ivacaftor, 50 mg of tezacaftor and 100 mg of elexacaftor, 56 tablets – 37.5 mg of ivacaftor, 50 mg of tezacaftor and 100 mg of elexacaftor

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