Kerendia (finerenone)

Kerendia (finerenone)

$756.04 – $2,268.12

Kerendia (finerenone) is a prescription medicine used to reduce the risk of kidney function decline, kidney failure, cardiovascular death, nonfatal heart attacks and hospitalization for heart failure in patients with chronic kidney disease associated with type 2 diabetes..

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What is Kerendia (finerenone) for?

Kerendia (finerenone) is a nonsteroidal mineralocorticoid receptor antagonist, or MRA, used to treat adults with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) to reduce the risk of:[1]

  • Worsening of kidney disease
  • End-stage kidney disease (ESKD)
  • Death due to cardiovascular disease
  • Heart attack
  • Hospitalization for heart failure

It is available in tablet form containing 10 mg or 20 mg of finerenone.[1]

How does Kerendia (finerenone) work?

The active ingredient in Kerendia, finerenone, is an inhibitor of the mineralocorticoid receptor (MR). Overactivation of the MR is thought to contribute to kidney and heart diseases, including CKD and diabetes, through inflammation and fibrosis that lead to progressive kidney and cardiovascular dysfunction.[2]

Where has Kerendia (finerenone) been approved?

Kerendia (finerenone) was approved for the treatment of people with diabetic kidney and heart disease by:

  • The Food and Drug Administration (FDA), USA on July 9, 2021.[3]

FDA granted Kerendia (finerenone) Priority Review and Fast Track designations for this application.[3]

Please note that this medicine may have also been approved in other regions than the ones weā€™ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Kerendia (finerenone) taken?

The standard dosage is:[1]

  • 10 mg or 20 mg tablets taken orally once daily. Dosage is based on estimated glomerular filtration rate (eGFR) and serum potassium measures.
  • The dosage should be increased after 4 weeks to the target dose of 20 mg once daily, based on eGFR and serum potassium levels.

The tablets may be taken with or without food.[1]

Warning: do not take this medicine if you:[1]

  • Have problems with your adrenal glands (adrenal insufficiency)
  • Take certain medications called CYP3A4 inhibitors.

Complete information about Kerendia (finerenone) dosage (adjustment) and administration can be found in the official prescribing information listed in our references section.[1]

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Kerendia (finerenone)?

Common adverse reactions

The most common side effects (ā‰„1% of patients) listed in the prescribing information include:[1]

  • Hyperkalemia (elevated potassium levels in your blood)
  • Hypotension (reduced blood pressure)
  • Hyponatremia (reduced sodium level in your blood)

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include:[1]

  • Hyperkalemia

Use in a specific population

It is not known what the effects of Kerendia (finerenone) are on an unborn fetus. It is advised to avoid pregnancy and breastfeeding during treatment.[1]

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.[1]

Package

30 tablets of 20 mg, 90 tablets of 10 mg, 90 tablets of 20 mg

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