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Trikafta* (Elexacaftor/Tezacaftor/Ivacaftor; Ivacaftor)
$47,642.65 – $51,734.09
Trikafta (elexacaftor/tezacaftor/ivacaftor; ivacaftor)* is a medication used for the treatment of cystic fibrosis (CF), indicated for CF patients aged 12 years and older with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that are responsive to Trikafta based on in vitro data.
What is Trikafta (elexacaftor/tezacaftor/ivacaftor)* for?
Trikafta (elexacaftor/tezacaftor/ivacaftor)* is a medication used in combination with ivacaftor 150 mg tablets for people with cystic fibrosis (CF) aged 12 years and older with at least one copy of the F508del mutation.
How effective is Trikafta (elexacaftor/tezacaftor/ivacaftor)* for cystic fibrosis?
The approval of Trikafta (elexacaftor/tezacaftor/ivacaftor)* for CF was based on two clinical studies.
Study 1
Included 403 people with CF, 12 years and older, with one copy of the F508del mutation and a mutation defined in the study. Trikafta was compared with placebo (a dummy treatment).
According to the study results published:
After 24 weeks, lung function (FEV1) improved significantly.
Study 2
Included 107 people with CF, 12 years and older, with two copies of the F508del mutation. Trikafta was compared with ivacaftor and tezacaftor (Symdeko).
According to the study results published:
There was significant improvement in lung function (FEV1).
For more details refer to the prescribing information at the bottom of the page.
Which side effects can I expect with Trikafta (elexacaftor/tezacaftor/ivacaftor)*?
According to the studies published ,the main common side effects of Trikafta (which may affect more than 1 in 10 people) in people with CF aged 12 years and older include headaches, upper respiratory tract infections, abdominal pains, diarrhea and rashes.
Please note this is not intended to be a comprehensive guide. Consult your treating doctor and the prescribing information at the bottom of the page for full details of side effects.
How is Trikafta (elexacaftor/tezacaftor/ivacaftor)* taken?

Administration: in the morning take two Trikafta tablets. In the evening, take one ivacaftor tablet. Take these tablets approximately 12 hours apart.
Dosage: 150 mg ivacaftor, 100 mg tezacaftor and 200 mg elexacaftor in the morning and 150 mg ivacaftor in the evening.
Co-Packaged Blister Pack | 84 tablets (fixed-dose combination containing 50 mg elexacaftor, 25 mg tezacaftor and 37.50 mg ivacaftor; 75 mg ivacaftor), 84 tablets (fixed-dose combination containing 100 mg elexacaftor, 50 mg tezacaftor and 75 mg ivacaftor; 150 mg ivacaftor) |
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